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The OpenAI Responses API replaces the Assistants API with a simpler, more flexible architecture for building AI agents. It eliminates threads by using previous_response_id to maintain conversation context, supports stateless instructions, and improves tool usage through built-in integrations like file search, web search, and code execution. Developers benefit from strong TypeScript support, easier state management, and new features like vector stores with batch uploads and metadata. Migration is straightforward and preserves existing functionality, while paving the way for future enhancements. With OpenAI planning full feature parity and eventual deprecation of the Assistants API, switching now ensures long-term compatibility.